Putative N-acetyltransferase 8B
Definition:
May have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1. May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons. May play a role in regulation of gastrulation (By similarity).
References:
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[1]. Anthony B Mak, et al. Post-translational regulation of CD133 by ATase1/ATase2-mediated lysine acetylation. J Mol Biol. 2014 May 29;426(11):2175-82. [Content Brief]
[2]. Mi Hee Ko, et al. Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels. J Biol Chem. 2009 Jan 23;284(4):2482-92. [Content Brief]
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