R-spondin-1

[1]. Dongli Wang, et al. Structural basis for R-spondin recognition by LGR4/5/6 receptors. Genes Dev. 2013 Jun 15;27(12):1339-44. [Content Brief]

[2]. Kyung-Ah Kim, et al. Mitogenic influence of human R-spondin1 on the intestinal epithelium. Science. 2005 Aug 19;309(5738):1256-9. [Content Brief]

[3]. Huai-Xiang Hao, et al. ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature. 2012 Apr 29;485(7397):195-200. [Content Brief]

[4]. Wim de Lau, et al. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature. 2011 Jul 4;476(7360):293-7. [Content Brief]

[5]. Heinz Ruffner, et al. R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5. PLoS One. 2012;7(7):e40976. [Content Brief]

[6]. Xing Gong, et al. LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor. PLoS One. 2012;7(5):e37137. [Content Brief]

[7]. Andrei Glinka, et al. LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling. EMBO Rep. 2011 Sep 30;12(10):1055-61. [Content Brief]

[8]. Minke E Binnerts, et al. R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14700-5. [Content Brief]

[9]. Emmanuelle Szenker-Ravi, et al. RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6. Nature. 2018 May;557(7706):564-569. [Content Brief]

[10]. Weng Chuan Peng, et al. Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5. Cell Rep. 2013 Jun 27;3(6):1885-92. [Content Brief]