Rab GTPase-binding effector protein 2

Definition:

Plays a role in membrane trafficking and in homotypic early endosome fusion. Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking. By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis.

References:

[1]. H Gournier, et al. Two distinct effectors of the small GTPase Rab5 cooperate in endocytic membrane fusion. EMBO J. 1998 Apr 1;17(7):1930-40. [Content Brief]

[2]. Rannar Airik, et al. SDCCAG8 Interacts with RAB Effector Proteins RABEP2 and ERC1 and Is Required for Hedgehog Signaling. PLoS One. 2016 May 25;11(5):e0156081. [Content Brief]

[3]. Natalie Kofler, et al. The Rab-effector protein RABEP2 regulates endosomal trafficking to mediate vascular endothelial growth factor receptor-2 (VEGFR2)-dependent signaling. J Biol Chem. 2018 Mar 30;293(13):4805-4817. [Content Brief]

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