Rab-like protein 3

Definition:

Required for KRAS signaling regulation and modulation of cell proliferation. Regulator of KRAS prenylation, and probably prenylation of other small GTPases. Required for lymphocyte development and function (By similarity). Not required for myeloid cell development (By similarity).

References:

[1]. Sahar Nissim, et al. Mutations in RABL3 alter KRAS prenylation and are associated with hereditary pancreatic cancer. Nat Genet. 2019 Sep;51(9):1308-1314. [Content Brief]

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