Rab proteins geranylgeranyltransferase component A 2

Definition:

Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family.

References:

[1]. F P Cremers, et al. REP-2, a Rab escort protein encoded by the choroideremia-like gene. J Biol Chem. 1994 Jan 21;269(3):2111-7. [Content Brief]

[2]. Vadim Sidorovitch, et al. Expression of mammalian Rab Escort protein-1 and -2 in yeast Saccharomyces cerevisiae. Protein Expr Purif. 2002 Oct;26(1):50-8. [Content Brief]

[3]. Alexey Rak, et al. Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease. Cell. 2004 Jun 11;117(6):749-60. [Content Brief]

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