Ras-related protein Rab-22A

Definition:

Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form.

References:

[1]. Liang Wang, et al. Rab22 controls NGF signaling and neurite outgrowth in PC12 cells. Mol Biol Cell. 2011 Oct;22(20):3853-60. [Content Brief]

[2]. Javier G Magadán, et al. Rab22a regulates the sorting of transferrin to recycling endosomes. Mol Cell Biol. 2006 Apr;26(7):2595-614. [Content Brief]

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