Ras-related protein Rab-27B

Definition:

Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1. May be involved in targeting uroplakins to urothelial apical membranes (By similarity).

References:

[1]. Jianjian Zhang, et al. DENN domain-containing protein FAM45A regulates the homeostasis of late/multivesicular endosomes. Biochim Biophys Acta Mol Cell Res. 2019 May;1866(5):916-929. [Content Brief]

[2]. Shu-Hong Huang, et al. JIP3 mediates TrkB axonal anterograde transport and enhances BDNF signaling by directly bridging TrkB with kinesin-1. J Neurosci. 2011 Jul 20;31(29):10602-14. [Content Brief]

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