Reticulon-3

Definition:

May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules. Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition.; (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses.

References:

[1]. Rong Xiang, et al. Adaptor FADD is recruited by RTN3/HAP in ER-bound signaling complexes. Apoptosis. 2006 Nov;11(11):1923-32. [Content Brief]

[2]. Wanxia He, et al. Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation. Nat Med. 2004 Sep;10(9):959-65. [Content Brief]

[3]. Takeshi Urade, et al. Identification and characterization of TMEM33 as a reticulon-binding protein. Kobe J Med Sci. 2014 Nov 6;60(3):E57-65. [Content Brief]

[4]. Wen-Fang Tang, et al. Reticulon 3 binds the 2C protein of enterovirus 71 and is required for viral replication. J Biol Chem. 2007 Feb 23;282(8):5888-98. [Content Brief]

[5]. Qingwen Wan, et al. Reticulon 3 mediates Bcl-2 accumulation in mitochondria in response to endoplasmic reticulum stress. Apoptosis. 2007 Feb;12(2):319-28. [Content Brief]

[6]. Yuichi Wakana, et al. Reticulon 3 is involved in membrane trafficking between the endoplasmic reticulum and Golgi. Biochem Biophys Res Commun. 2005 Sep 9;334(4):1198-205. [Content Brief]

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