Retinal guanylyl cyclase 1

Definition:

Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment. May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity).

References:

[1]. C L Tucker, et al. Two amino acid substitutions convert a guanylyl cyclase, RetGC-1, into an adenylyl cyclase. Proc Natl Acad Sci U S A. 1998 May 26;95(11):5993-7. [Content Brief]

[2]. Hanna Wimberg, et al. Photoreceptor Guanylate Cyclase ( GUCY2D) Mutations Cause Retinal Dystrophies by Severe Malfunction of Ca2+-Dependent Cyclic GMP Synthesis. Front Mol Neurosci. 2018 Sep 25;11:348. [Content Brief]

[3]. Igor V Peshenko, et al. Retinal degeneration 3 (RD3) protein inhibits catalytic activity of retinal membrane guanylyl cyclase (RetGC) and its stimulation by activating proteins. Biochemistry. 2011 Nov 8;50(44):9511-9. [Content Brief]

[4]. Igor V Peshenko, et al. Dimerization Domain of Retinal Membrane Guanylyl Cyclase 1 (RetGC1) Is an Essential Part of Guanylyl Cyclase-activating Protein (GCAP) Binding Interface. J Biol Chem. 2015 Aug 7;290(32):19584-96. [Content Brief]

[5]. Chandra L Tucker, et al. Functional analyses of mutant recessive GUCY2D alleles identified in Leber congenital amaurosis patients: protein domain comparisons and dominant negative effects. Mol Vis. 2004 Apr 20;10:297-303. [Content Brief]

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