Rho guanine nucleotide exchange factor 15

Definition:

Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2.

References:

[1]. Hisakazu Ogita, et al. EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically in vascular smooth muscle cells. Circ Res. 2003 Jul 11;93(1):23-31. [Content Brief]

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