Ribonuclease T2

Definition

Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8. Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides. In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8. Also plays a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria. Participates as well in degradation of mitochondrion-associated cytosolic rRNAs.

References:

[1]. Wilhelm Greulich, et al. TLR8 Is a Sensor of RNase T2 Degradation Products. Cell. 2019 Nov 27;179(6):1264-1275.e13. [Content Brief]

[2]. Andrea Thorn, et al. Structure and activity of the only human RNase T2. Nucleic Acids Res. 2012 Sep 1;40(17):8733-42. [Content Brief]

[3]. Ying Cheng, et al. Mitochondrial Trafficking and Processing of Telomerase RNA TERC. Cell Rep. 2018 Sep 4;24(10):2589-2595. [Content Brief]

[4]. Peipei Liu, et al. Mammalian mitochondrial RNAs are degraded in the mitochondrial intermembrane space by RNASET2. Protein Cell. 2017 Oct;8(10):735-749. [Content Brief]

[5]. Marco Henneke, et al. RNASET2-deficient cystic leukoencephalopathy resembles congenital cytomegalovirus brain infection. Nat Genet. 2009 Jul;41(7):773-5. [Content Brief]

[6]. Paola Campomenosi, et al. Characterization of RNASET2, the first human member of the Rh/T2/S family of glycoproteins. Arch Biochem Biophys. 2006 May 15;449(1-2):17-26. [Content Brief]

[7]. Jinliang Huang, et al. Regulation of mitochondrion-associated cytosolic ribosomes by mammalian mitochondrial ribonuclease T2 (RNASET2). J Biol Chem. 2018 Dec 21;293(51):19633-19644. [Content Brief]

生物医学辞典

生物医学辞典は、生物学の学術用語と専門データの包括的で専門的なデータベースです。すべての説明は、権威ある書籍や高いＩＦの文献に基づいており、知りたい生物医学用語の正確な説明を得ることができます。

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