Rootletin
Definition:
Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis. Contributes to centrosome cohesion before mitosis.
References:
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[1]. Inna V Nechipurenko, et al. A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis. Dev Cell. 2016 Sep 12;38(5):493-506. [Content Brief]
[2]. Susanne Bahe, et al. Rootletin forms centriole-associated filaments and functions in centrosome cohesion. J Cell Biol. 2005 Oct 10;171(1):27-33. [Content Brief]
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