Rotatin

Definition:

Involved in the genetic cascade that governs left-right specification. Plays a role in the maintenance of a normal ciliary structure. Required for correct asymmetric expression of NODAL, LEFTY and PITX2.

References:

[1]. Sima Kheradmand Kia, et al. RTTN mutations link primary cilia function to organization of the human cerebral cortex. Am J Hum Genet. 2012 Sep 7;91(3):533-40. [Content Brief]

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