SAGA-associated factor 29

Definition:

Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me. Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival. Also binds non-histone proteins that are methylated on Lys residues: specifically recognizes and binds CGAS monomethylated on 'Lys-506' (By similarity).

References:

[1]. Jos J A G Kamps, et al. Chemical basis for the recognition of trimethyllysine by epigenetic reader proteins. Nat Commun. 2015 Nov 18;6:8911. [Content Brief]

[2]. Sebastián Guelman, et al. The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Mol Cell Biol. 2009 Mar;29(5):1176-88. [Content Brief]

[3]. Chuanbing Bian, et al. Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. EMBO J. 2011 Jun 17;30(14):2829-42. [Content Brief]

[4]. Michiel Vermeulen, et al. Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. Cell. 2010 Sep 17;142(6):967-80. [Content Brief]

[5]. Bas J G E Pieters, et al. The Role of Electrostatic Interactions in Binding of Histone H3K4me2/3 to the Sgf29 Tandem Tudor Domain. PLoS One. 2015 Sep 30;10(9):e0139205. [Content Brief]

[6]. Andrea W Schram, et al. A dual role for SAGA-associated factor 29 (SGF29) in ER stress survival by coordination of both histone H3 acetylation and histone H3 lysine-4 trimethylation. PLoS One. 2013 Jul 23;8(7):e70035. [Content Brief]

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