SCL-interrupting locus protein

Definition:

Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1. Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CENPJ to the base of the procentriole to initiate procentriole assembly.

References:

[1]. S Izraeli, et al. Expression of the SIL gene is correlated with growth induction and cellular proliferation. Cell Growth Differ. 1997 Nov;8(11):1171-9. [Content Brief]

[2]. Stefano Campaner, et al. Sil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpoint. Mol Cell Biol. 2005 Aug;25(15):6660-72. [Content Brief]

[3]. Chieh-Ju C Tang, et al. The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation. EMBO J. 2011 Oct 21;30(23):4790-804. [Content Brief]

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