SEC14-like protein 1

Definition:

May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of RIGI, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of RIGI with MAVS/IPS1, an important step in signal propagation. May also regulate the SLC18A3 and SLC5A7 cholinergic transporters.

References:

[1]. Fabíola M Ribeiro, et al. SEC14-like protein 1 interacts with cholinergic transporters. Neurochem Int. 2007 Jan;50(2):356-64. [Content Brief]

[2]. Meng-Tong Li, et al. Negative regulation of RIG-I-mediated innate antiviral signaling by SEC14L1. J Virol. 2013 Sep;87(18):10037-46. [Content Brief]

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