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Secondary hyperparathyroidism

Definition:

Secondary hyperparathyroidism (SHPT) is a chronic and progressive disorder characterized by elevated serum parathyroid hormone (PTH), parathyroid gland hyperplasia, and disturbances in mineral metabolism, mainly calcium and phosphorus. SHPT is generally caused by diffuse parathyroid hyperplasia in response to prolonged reduced levels of extracellular calcium from various secondary aetiologies. Because SHPT is a compensatory mechanism of the parathyroid glands, it commonly resolves with normalization of calcium and phosphorus homeostasis. After excluding reversible secondary aetiologies, first-line treatment of irreversible SHPT (often related to chronic kidney disease) mainly involves medical therapies.

References:

[1]. Kai Duan, et al. Clinicopathological correlates of hyperparathyroidism. J Clin Pathol. 2015 Oct;68(10):771-87. [Content Brief]

[2]. Mario Cozzolino, et al. Emerging drugs for secondary hyperparathyroidism. Expert Opin Emerg Drugs. 2015 Jun;20(2):197-208. [Content Brief]

[3]. Naoto Hamano, et al. Etelcalcetide for the treatment of secondary hyperparathyroidism. Expert Opin Pharmacother. 2017 Apr;18(5):529-534. [Content Brief]

[4]. Noah K Yuen, et al. Hyperparathyroidism of Renal Disease. Perm J. 2016 Summer;20(3):15-127. [Content Brief]

[5]. T Akiba, et al. Controlled trial of falecalcitriol versus alfacalcidol in suppression of parathyroid hormone in hemodialysis patients with secondary hyperparathyroidism. Am J Kidney Dis. 1998 Aug;32(2):238-46. [Content Brief]

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