Secretogranin-3

Definition:

Member of the granin protein family that regulates the biogenesis of secretory granules. Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By similarity). May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway.

References:

[1]. Fen Tang, et al. Secretogranin III promotes angiogenesis through MEK/ERK signaling pathway. Biochem Biophys Res Commun. 2018 Jan 1;495(1):781-786. [Content Brief]

[2]. Kikuko Hotta, et al. Secretogranin II binds to secretogranin III and forms secretory granules with orexin, neuropeptide Y, and POMC. J Endocrinol. 2009 Jul;202(1):111-21. [Content Brief]

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