Sentrin-specific protease 8

Definition:

Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.

References:

[1]. Dimitris P Xirodimas, et al. Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell. 2004 Jul 9;118(1):83-97. [Content Brief]

[2]. Heidi M Mendoza, et al. NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins. J Biol Chem. 2003 Jul 11;278(28):25637-43. [Content Brief]

[3]. Lin-nan Shen, et al. Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1. EMBO J. 2005 Apr 6;24(7):1341-51. [Content Brief]

[4]. Tudeviin Gan-Erdene, et al. Identification and characterization of DEN1, a deneddylase of the ULP family. J Biol Chem. 2003 Aug 1;278(31):28892-900. [Content Brief]

[5]. Kenneth Wu, et al. DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1. J Biol Chem. 2003 Aug 1;278(31):28882-91. [Content Brief]

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