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Serglycin

Definition:

Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.

References:

[1]. Lillian Zernichow, et al. Secretion of proteases in serglycin transfected Madin-Darby canine kidney cells. FEBS J. 2006 Feb;273(3):536-47. [Content Brief]

[2]. Achilleas D Theocharis, et al. Serglycin constitutively secreted by myeloma plasma cells is a potent inhibitor of bone mineralization in vitro. J Biol Chem. 2006 Nov 17;281(46):35116-28. [Content Brief]

[3]. Sunil S Metkar, et al. Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation. Immunity. 2002 Mar;16(3):417-28. [Content Brief]

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