Serine hydroxymethyltransferse (SHMT)

Definition:

Serine hydroxymethyltransferse (SHMT) is a pyridoxal phosphate (Vitamin B6) dependent enzyme, plays an important role in cellular one-carbon pathways. Serine hydroxymethyltransferse (SHMT) catalyzes the reversible, simultaneous conversions of L-serine to glycine and tetrahydrofolate (THF) to 5,10-Methylenetetrahydrofolate (5,10-CH2-THF).

References:

[1]. Florio R, et al. Serine hydroxymethyltransferase: a model enzyme for mechanistic, structural, and evolutionary studies. Biochim Biophys Acta. 2011 Nov;1814(11):1489-96. [Content Brief]

[2]. Appaji Rao N, et al. Structure-function relationship in serine hydroxymethyltransferase. Biochim Biophys Acta. 2003 Apr 11;1647(1-2):24-9. [Content Brief]

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