Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
Definition:
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). May play a role in skeletal muscle fiber type specification (By similarity).
References:
-
[1]. Sheng-Jie Li, et al. Cooperative autoinhibition and multi-level activation mechanisms of calcineurin. Cell Res. 2016 Mar;26(3):336-49. [Content Brief]
[2]. Susann Kilka, et al. The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding. Biochemistry. 2009 Mar 10;48(9):1900-10. [Content Brief]
Biomedical Dictionary
The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.
Molarity Calculator
Dilution Calculator
