Seven in absentia homolog 3

Definition:

Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria.

References:

[1]. Samuel A Hasson, et al. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Nature. 2013 Dec 12;504(7479):291-5. [Content Brief]

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