Sialidase-3

Definition:

Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR. Desialylates EGFR and activates downstream signaling in proliferating cells. Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes.

References:

[1]. Kazunori Yamaguchi, et al. Evidence for mitochondrial localization of a novel human sialidase (NEU4). Biochem J. 2005 Aug 15;390(Pt 1):85-93. [Content Brief]

[2]. T Wada, et al. A crucial role of plasma membrane-associated sialidase in the survival of human cancer cells. Oncogene. 2007 Apr 12;26(17):2483-90. [Content Brief]

[3]. T Wada, et al. Cloning, expression, and chromosomal mapping of a human ganglioside sialidase. Biochem Biophys Res Commun. 1999 Jul 22;261(1):21-7. [Content Brief]

[4]. Macarena Rodriguez-Walker, et al. Human Sialidase Neu3 is S-Acylated and Behaves Like an Integral Membrane Protein. Sci Rep. 2017 Jun 23;7(1):4167. [Content Brief]

[5]. Macarena Rodriguez-Walker, et al. Role of plasma-membrane-bound sialidase NEU3 in clathrin-mediated endocytosis. Biochem J. 2015 Aug 15;470(1):131-44. [Content Brief]

[6]. E Monti, et al. Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane. Biochem J. 2000 Jul 1;349(Pt 1):343-51. [Content Brief]

[7]. Yan Wang, et al. A close association of the ganglioside-specific sialidase Neu3 with caveolin in membrane microdomains. J Biol Chem. 2002 Jul 19;277(29):26252-9. [Content Brief]

[8]. Alessandra Mozzi, et al. NEU3 activity enhances EGFR activation without affecting EGFR expression and acts on its sialylation levels. Glycobiology. 2015 Aug;25(8):855-68. [Content Brief]

[9]. Amgad Albohy, et al. Insight into substrate recognition and catalysis by the human neuraminidase 3 (NEU3) through molecular modeling and site-directed mutagenesis. Glycobiology. 2010 Sep;20(9):1127-38. [Content Brief]

[10]. Y Wang, et al. Site-directed mutagenesis of human membrane-associated ganglioside sialidase: identification of amino-acid residues contributing to substrate specificity. Eur J Biochem. 2001 Apr;268(8):2201-8. [Content Brief]

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