Signal peptidase complex subunit 3

Definition:

Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity).; (Microbial infection) Plays an important role in virion production of flaviviruses such as West Nile virus, Japanese enchephalitis virus, Dengue virus type 2 and Yellow Fever virus.

References:

[1]. Rong Zhang, et al. A CRISPR screen defines a signal peptide processing pathway required by flaviviruses. Nature. 2016 Jul 7;535(7610):164-8. [Content Brief]

[2]. A Manuel Liaci, et al. Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage. Mol Cell. 2021 Oct 7;81(19):3934-3948.e11. [Content Brief]

[3]. Qiuyue Chen, et al. Inverting the Topology of a Transmembrane Protein by Regulating the Translocation of the First Transmembrane Helix. Mol Cell. 2016 Aug 18;63(4):567-578. [Content Brief]

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