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  2. Sirtuin1 (SIRT1)

Sirtuin1 (SIRT1)

Definition:

Sirtuin1 (SIRT1) is a class-III histone deacetylase (HDAC), an NAD+-dependent enzyme deeply involved in gene regulation, genome stability maintenance, apoptosis, autophagy, senescence, proliferation, aging, and tumorigenesis. It also has a key role in the epigenetic regulation of tissue homeostasis and many diseases by deacetylating both histone and non-histone targets.

Biomedical Dictionary

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