Sodium-coupled neutral amino acid transporter 7

Definition:

Symporter that selectively cotransports sodium ions and amino acids, such as L-glutamine and L-asparagine from the lysosome into the cytoplasm and may participates in mTORC1 activation. The transport activity requires an acidic lysosomal lumen.

References:

[1]. Delong Meng, et al. SNAT7 regulates mTORC1 via macropinocytosis. Proc Natl Acad Sci U S A. 2022 May 17;119(20):e2123261119. [Content Brief]

[2]. Quentin Verdon, et al. SNAT7 is the primary lysosomal glutamine exporter required for extracellular protein-dependent growth of cancer cells. Proc Natl Acad Sci U S A. 2017 May 2;114(18):E3602-E3611. [Content Brief]

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