Sodium-dependent serotonin transporter

Definition:

Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.

References:

[1]. B Brenner, et al. Plasma serotonin levels and the platelet serotonin transporter. J Neurochem. 2007 Jul;102(1):206-15. [Content Brief]

[2]. Jonathan A Coleman, et al. X-ray structures and mechanism of the human serotonin transporter. Nature. 2016 Apr 21;532(7599):334-9. [Content Brief]

[3]. Fusun Kilic, et al. A human serotonin transporter mutation causes constitutive activation of transport activity. Mol Pharmacol. 2003 Aug;64(2):440-6. [Content Brief]

[4]. O V Mortensen, et al. Molecular cloning, expression and characterization of a bovine serotonin transporter. Brain Res Mol Brain Res. 1999 Jul 23;71(1):120-6. [Content Brief]

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