Sodium/myo-inositol cotransporter 2

Definition:

Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine (By similarity). Can also transport D-chiro-inositol (DCI) but not L-fucose. Exhibits stereospecific cotransport of both D-glucose and D-xylose (By similarity). May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney (By similarity).

References:

[1]. P M W Groenen, et al. Spina bifida and genetic factors related to myo-inositol, glucose, and zinc. Mol Genet Metab. 2004 Jun;82(2):154-61. [Content Brief]

[2]. L-J Tsai, et al. The sodium-dependent glucose cotransporter SLC5A11 as an autoimmune modifier gene in SLE. Tissue Antigens. 2008 Feb;71(2):114-26. [Content Brief]

[3]. Xiaobo Lin, et al. Human sodium/inositol cotransporter 2 (SMIT2) transports inositols but not glucose in L6 cells. Arch Biochem Biophys. 2009 Jan 15;481(2):197-201. [Content Brief]

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