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Sororin

Definition:

Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair.

References:

[1]. Tomoko Nishiyama, et al. Sororin mediates sister chromatid cohesion by antagonizing Wapl. Cell. 2010 Nov 24;143(5):737-49. [Content Brief]

[2]. Julia Schmitz, et al. Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase. Curr Biol. 2007 Apr 3;17(7):630-6. [Content Brief]

[3]. Susannah Rankin, et al. Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates. Mol Cell. 2005 Apr 15;18(2):185-200. [Content Brief]

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