Sorting nexin-33

Definition:

Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.

References:

[1]. Maggie P C Ma, et al. SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis. J Cell Sci. 2012 Sep 15;125(Pt 18):4372-82. [Content Brief]

[2]. Andreas Heiseke, et al. The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding. Traffic. 2008 Jul;9(7):1116-29. [Content Brief]

[3]. Jack T H Wang, et al. The SNX-PX-BAR family in macropinocytosis: the regulation of macropinosome formation by SNX-PX-BAR proteins. PLoS One. 2010 Oct 29;5(10):e13763. [Content Brief]

[4]. Bastian Dislich, et al. Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33. Biochem J. 2011 Jan 1;433(1):75-83. [Content Brief]

[5]. Susanne Schöbel, et al. A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein. J Biol Chem. 2008 May 23;283(21):14257-68. [Content Brief]

[6]. Juan Zhang, et al. Sorting nexin 33 induces mammalian cell micronucleated phenotype and actin polymerization by interacting with Wiskott-Aldrich syndrome protein. J Biol Chem. 2009 Aug 7;284(32):21659-69. [Content Brief]

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