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SOSS complex subunit B1

Definition:

Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.

References:

[1]. Jun Huang, et al. SOSS complexes participate in the maintenance of genomic stability. Mol Cell. 2009 Aug 14;35(3):384-93. [Content Brief]

[2]. Derek J Richard, et al. Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature. 2008 May 29;453(7195):677-81. [Content Brief]

[3]. Yongjiang Li, et al. HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response. J Biol Chem. 2009 Aug 28;284(35):23525-31. [Content Brief]

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