Speedy protein A

Definition:

Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2. Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation. Mediates cell survival during the DNA damage process through activation of CDK2.

References:

[1]. Lisa A Porter, et al. Spy1 interacts with p27Kip1 to allow G1/S progression. Mol Biol Cell. 2003 Sep;14(9):3664-74. [Content Brief]

[2]. Elizabeth A Barnes, et al. Human Spy1 promotes survival of mammalian cells following DNA damage. Cancer Res. 2003 Jul 1;63(13):3701-7. [Content Brief]

[3]. Denise A McGrath, et al. Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins. EMBO J. 2017 Aug 1;36(15):2251-2262. [Content Brief]

[4]. Lisa A Porter, et al. Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2. J Cell Biol. 2002 Apr 29;157(3):357-66. [Content Brief]

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