Spike protein

Definition:

Spike protein is the spike (S) protein of Severe acute respiratory syndrome coronavirus-2(SARS CoV-2), which plays a key role in the receptor recognition and cell membrane fusion process. Spike protein is composed of two subunits, S1 and S2. S1 recognizes and binds to the host receptor angiotensin-converting enzyme 2 (ACE2), while S2 mediates viral cell membrane fusion.

References:

[1]. Huang Y, et al. Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19. Acta Pharmacol Sin. 2020 Sep;41(9):1141-1149. [Content Brief]

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