Splicing factor 3A subunit 1

Definition:

Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes.

References:

[1]. R Das, et al. Functional association of U2 snRNP with the ATP-independent spliceosomal complex E. Mol Cell. 2000 May;5(5):779-87. [Content Brief]

[2]. Xiaofeng Zhang, et al. Structure of the human activated spliceosome in three conformational states. Cell Res. 2018 Mar;28(3):307-322. [Content Brief]

[3]. Xiechao Zhan, et al. Structures of the human pre-catalytic spliceosome and its precursor spliceosome. Cell Res. 2018 Dec;28(12):1129-1140. [Content Brief]

[4]. D Nesic, et al. Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation. Mol Cell Biol. 2001 Oct;21(19):6406-17. [Content Brief]

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