Src kinase-associated phosphoprotein 1

Definition:

Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.

References:

[1]. Hongyan Wang, et al. SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates. Nat Immunol. 2003 Apr;4(4):366-74. [Content Brief]

[2]. Liangtang Wu, et al. SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription. Mol Cell Biol. 2002 Apr;22(8):2673-86. [Content Brief]

[3]. H Kang, et al. SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55. EMBO J. 2000 Jun 15;19(12):2889-99. [Content Brief]

[4]. Eun-Kyeong Jo, et al. An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R. J Exp Med. 2005 Jun 6;201(11):1733-9. [Content Brief]

[5]. Stefanie Kliche, et al. The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1. Mol Cell Biol. 2006 Oct;26(19):7130-44. [Content Brief]

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