Surfeit locus protein 4

Definition:

Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion. Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis. Synergizes with the GTPase SAR1B to mediate transport of circulating lipoproteins. Promotes the secretion of PCSK9. Also mediates the efficient secretion of erythropoietin (EPO). May also play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi.

References:

[1]. Brian T Emmer, et al. The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9. Elife. 2018 Sep 25;7:e38839. [Content Brief]

[2]. Xiao Wang, et al. Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans. Cell Metab. 2021 Feb 2;33(2):350-366.e7. [Content Brief]

[3]. Zesen Lin, et al. The Endoplasmic Reticulum Cargo Receptor SURF4 Facilitates Efficient Erythropoietin Secretion. Mol Cell Biol. 2020 Nov 6;40(23):e00180-20. [Content Brief]

[4]. Keiko Saegusa, et al. SFT-4/Surf4 control ER export of soluble cargo proteins and participate in ER exit site organization. J Cell Biol. 2018 Jun 4;217(6):2073-2085. [Content Brief]

[5]. Sandra Mitrovic, et al. The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi. Mol Biol Cell. 2008 May;19(5):1976-90. [Content Brief]

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