Switch-associated protein 70

Definition:

Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).

References:

[1]. L Masat, et al. Association of SWAP-70 with the B cell antigen receptor complex. Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2180-4. [Content Brief]

[2]. Pirta Hilpelä, et al. SWAP-70 identifies a transitional subset of actin filaments in motile cells. Mol Biol Cell. 2003 Aug;14(8):3242-53. [Content Brief]

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