Symplekin

Definition:

Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity.

References:

[1]. Kehui Xiang, et al. Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex. Nature. 2010 Oct 7;467(7316):729-33. [Content Brief]

[2]. Nikolay G Kolev, et al. Symplekin and multiple other polyadenylation factors participate in 3'-end maturation of histone mRNAs. Genes Dev. 2005 Nov 1;19(21):2583-92. [Content Brief]

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