Synaptic vesicle glycoprotein 2C
Definition:
References:
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[1]. Lisheng Peng, et al. Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors. PLoS Pathog. 2011 Mar;7(3):e1002008. [Content Brief]
[2]. Roger M Benoit, et al. Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A. Nature. 2014 Jan 2;505(7481):108-11. [Content Brief]
[3]. Guorui Yao, et al. N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A. Nat Struct Mol Biol. 2016 Jul;23(7):656-62. [Content Brief]
[4]. Roger M Benoit, et al. Crystal structure of the BoNT/A2 receptor-binding domain in complex with the luminal domain of its neuronal receptor SV2C. Sci Rep. 2017 Mar 2;7:43588. [Content Brief]
[5]. Robert Gustafsson, et al. Crystal Structure of Botulinum Neurotoxin A2 in Complex with the Human Protein Receptor SV2C Reveals Plasticity in Receptor Binding. Toxins (Basel). 2018 Apr 12;10(4):153. [Content Brief]
[6]. Stefan Mahrhold, et al. Only the complex N559-glycan in the synaptic vesicle glycoprotein 2C mediates high affinity binding to botulinum neurotoxin serotype A1. Biochem J. 2016 Sep 1;473(17):2645-54. [Content Brief]
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