Testis-specific Y-encoded-like protein 2
Definition:
Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.
References:
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[1]. Z Chai, et al. SET-related cell division autoantigen-1 (CDA1) arrests cell growth. J Biol Chem. 2001 Sep 7;276(36):33665-74. [Content Brief]
[2]. Yugang Tu, et al. Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21(Waf1/Cip1) by activating p53 and MEK/ERK1/2 MAPK pathways. J Biol Chem. 2007 Apr 20;282(16):11722-31. [Content Brief]
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