Triple functional domain protein
Definition:
References:
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[1]. A Debant, et al. The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains. Proc Natl Acad Sci U S A. 1996 May 28;93(11):5466-71. [Content Brief]
[2]. Katrin Deinhardt, et al. Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac. Sci Signal. 2011 Dec 6;4(202):ra82. [Content Brief]
[3]. Reuben J Pengelly, et al. Mutations specific to the Rac-GEF domain of TRIO cause intellectual disability and microcephaly. J Med Genet. 2016 Nov;53(11):735-742. [Content Brief]
[4]. Sónia Barbosa, et al. Opposite Modulation of RAC1 by Mutations in TRIO Is Associated with Distinct, Domain-Specific Neurodevelopmental Disorders. Am J Hum Genet. 2020 Mar 5;106(3):338-355. [Content Brief]
[5]. K Seipel, et al. Trio amino-terminal guanine nucleotide exchange factor domain expression promotes actin cytoskeleton reorganization, cell migration and anchorage-independent cell growth. J Cell Sci. 1999 Jun;112 ( Pt 12):1825-34. [Content Brief]
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