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U-937

Definition:

U-937 is a human cancer cell line derived from Pleural effusion and associated with Adult acute monocytic leukemia and Acute monoblastic/monocytic leukemia. Its continuous tumor-cell growth supports reproducible mechanistic and pharmacological experiments. U-937 is used as an in vitro model of Adult acute monocytic leukemia and Acute monoblastic/monocytic leukemia to investigate cell differentiation.

References:

[1]. Lykov AP, et al. The Formation of Non-Specific Immunological Memory Phenotype in Human Monocyte-Like THP-1 and U-937 Cell Lines. Bulletin of experimental biology and medicine. 2023;175(4):477-480.

[2]. Abrink M, et al. Human cell lines U-937, THP-1 and Mono Mac 6 represent relatively immature cells of the monocyte-macrophage cell lineage. Leukemia. 1994;8(9):1579-84.

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