Ubiquitin carboxyl-terminal hydrolase 17

Definition:

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors RIGI and IFIH1 stimulates the cellular response to viral infection.

References:

[1]. Rui Chen, et al. The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling. Cell Res. 2010 Jul;20(7):802-11. [Content Brief]

[2]. Yaron Pereg, et al. Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A. Nat Cell Biol. 2010 Apr;12(4):400-6. [Content Brief]

[3]. Suresh Ramakrishna, et al. Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. J Biol Chem. 2011 Mar 25;286(12):10505-14. [Content Brief]

[4]. James F Burrows, et al. USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity. J Biol Chem. 2009 Apr 3;284(14):9587-95. [Content Brief]

[5]. James F Burrows, et al. DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation. J Biol Chem. 2004 Apr 2;279(14):13993-4000. [Content Brief]

[6]. Ju-Mi Shin, et al. Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability. BMC Genomics. 2006 Nov 16;7:292. [Content Brief]

[7]. Michelle de la Vega, et al. The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility. Nat Commun. 2011 Mar 29;2:259. [Content Brief]

[8]. Michelle de la Vega, et al. The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected. J Biol Chem. 2010 Apr 16;285(16):12028-36. [Content Brief]

[9]. Cheryl McFarlane, et al. The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression. Cancer Res. 2010 Apr 15;70(8):3329-39. [Content Brief]

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