UL16-binding protein 6
Definition:
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
References:
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[1]. Robert A Eagle, et al. ULBP6/RAET1L is an additional human NKG2D ligand. Eur J Immunol. 2009 Nov;39(11):3207-16. [Content Brief]
[2]. Jianmin Zuo, et al. A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding. Sci Signal. 2017 May 30;10(481):eaai8904. [Content Brief]
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