Urea transporter 2

Definition:

[Isoform 1]: Mediates the transport of urea driven by a concentration gradient across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism.; [Isoform 2]: Mediates the transport of urea driven by a concentration gradient across the cell membrane of the kidney inner medullary collecting duct which is critical to the urinary concentrating mechanism.

References:

[1]. B Olivès, et al. Molecular characterization of a new urea transporter in the human kidney. FEBS Lett. 1996 May 20;386(2-3):156-60. [Content Brief]

[2]. Abinash C Mistry, et al. The UT-A1 urea transporter interacts with snapin, a SNARE-associated protein. J Biol Chem. 2007 Oct 12;282(41):30097-106. [Content Brief]

[3]. S Martial, et al. Functional differentiation of the human red blood cell and kidney urea transporters. Am J Physiol. 1996 Dec;271(6 Pt 2):F1264-8. [Content Brief]

[4]. S M Bagnasco, et al. Cloning and characterization of the human urea transporter UT-A1 and mapping of the human Slc14a2 gene. Am J Physiol Renal Physiol. 2001 Sep;281(3):F400-6. [Content Brief]

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