Vitamin K-dependent protein C
Definition:
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.
References:
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[1]. Qiulan Ding, et al. Protein C Thr315Ala variant results in gain of function but manifests as type II deficiency in diagnostic assays. Blood. 2015 Apr 9;125(15):2428-34. [Content Brief]
[2]. Kitti B Kovács, et al. Molecular characterization of p.Asp77Gly and the novel p.Ala163Val and p.Ala163Glu mutations causing protein C deficiency. Thromb Res. 2015 Apr;135(4):718-26. [Content Brief]
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