Wings apart-like protein homolog

Definition:

Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.

References:

[1]. Marie-Emilie Terret, et al. Cohesin acetylation speeds the replication fork. Nature. 2009 Nov 12;462(7270):231-4. [Content Brief]

[2]. Stephanie Kueng, et al. Wapl controls the dynamic association of cohesin with chromatin. Cell. 2006 Dec 1;127(5):955-67. [Content Brief]

[3]. Tomoko Nishiyama, et al. Sororin mediates sister chromatid cohesion by antagonizing Wapl. Cell. 2010 Nov 24;143(5):737-49. [Content Brief]

[4]. Zhuqing Ouyang, et al. Structure of the human cohesin inhibitor Wapl. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11355-60. [Content Brief]

[5]. Keishi Shintomi, et al. Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1. Genes Dev. 2009 Sep 15;23(18):2224-36. [Content Brief]

[6]. Rita Gandhi, et al. Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase. Curr Biol. 2006 Dec 19;16(24):2406-17. [Content Brief]

[7]. Kosuke Oikawa, et al. Expression of a novel human gene, human wings apart-like (hWAPL), is associated with cervical carcinogenesis and tumor progression. Cancer Res. 2004 May 15;64(10):3545-9. [Content Brief]

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