Zinc finger CCCH domain-containing protein 4
Definition:
RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein. Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome. The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs.
References:
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[1]. Chris Estell, et al. ZC3H4 restricts non-coding transcription in human cells. Elife. 2021 Apr 29;10:e67305. [Content Brief]
[2]. Liv M I Austenaa, et al. A first exon termination checkpoint preferentially suppresses extragenic transcription. Nat Struct Mol Biol. 2021 Apr;28(4):337-346. [Content Brief]
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