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  3. Drug Derivative
  4. BMY-21502

BMY-21502 (BMS-181168) is a pyrrolidinone derivative with memory- and cognition-enhancing activities. BMS-181168 attenuates hypoxia-induced deterioration in brain function, as delta/theta decreases, alpha activity increases and the centroid of the combined delta/theta waves is accelerated.

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BMY-21502

BMY-21502 Chemical Structure

CAS No. : 123259-91-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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5 mg In-stock
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Description

BMY-21502 (BMS-181168) is a pyrrolidinone derivative with memory- and cognition-enhancing activities. BMS-181168 attenuates hypoxia-induced deterioration in brain function, as delta/theta decreases, alpha activity increases and the centroid of the combined delta/theta waves is accelerated[1].

Molecular Weight

328.33

Formula

C15H19F3N4O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(CC2CCN(CC2)C3=NC(C(F)(F)F)=NC=C3)CCC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (304.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0457 mL 15.2286 mL 30.4572 mL
5 mM 0.6091 mL 3.0457 mL 6.0914 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0457 mL 15.2286 mL 30.4572 mL 76.1429 mL
5 mM 0.6091 mL 3.0457 mL 6.0914 mL 15.2286 mL
10 mM 0.3046 mL 1.5229 mL 3.0457 mL 7.6143 mL
15 mM 0.2030 mL 1.0152 mL 2.0305 mL 5.0762 mL
20 mM 0.1523 mL 0.7614 mL 1.5229 mL 3.8071 mL
25 mM 0.1218 mL 0.6091 mL 1.2183 mL 3.0457 mL
30 mM 0.1015 mL 0.5076 mL 1.0152 mL 2.5381 mL
40 mM 0.0761 mL 0.3807 mL 0.7614 mL 1.9036 mL
50 mM 0.0609 mL 0.3046 mL 0.6091 mL 1.5229 mL
60 mM 0.0508 mL 0.2538 mL 0.5076 mL 1.2690 mL
80 mM 0.0381 mL 0.1904 mL 0.3807 mL 0.9518 mL
100 mM 0.0305 mL 0.1523 mL 0.3046 mL 0.7614 mL
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMY-21502123259-91-6BMS-181168BMY21502BMY 21502BMS181168BMS 181168Drug DerivativeDrug derivativepyrrolidinone derivativememory- and cognition-enhancingdeteriorationbrain functionInhibitorinhibitorinhibit

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